Ammonul

CLINICAL PHARMACOLOGY

AMMONUL^® is a combination of sodium phenylacetate and sodium benzoate, which are metabolically active compounds that can serve as alternatives to urea for the excretion of waste nitrogen.

Phenylacetate conjugates with glutamine in the liver and kidneys to form phenylacetylglutamine, via acetylation. Phenylacetylglutamine is excreted by the kidneys via glomerular filtration and tubular secretion. The nitrogen content of phenylacetylglutamine per mole is identical to that of urea (both contain two moles of nitrogen).

Similarly, preceded by acylation, benzoate conjugates with glycine to form hippuric acid (hippurate), which is rapidly excreted by the kidney through glomerular filtration and tubular secretion. One mole of hippuric acid contains one mole of waste nitrogen.